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The pattern of RPE loss in choroideremia can be predicted by applying simple rules. Also, our model predicts a residual island of RPE that resembles the topographic distribution of residual RPE seen in choroideremia. When the neighbor effect multiplies the background effect using the rod density function, our model follows an exponential decay, similar to previous observations. An additive neighbor effect alone does not simulate exponential decay. The main outcome measures: included topography of atrophy over time and fit of simulated residual RPE area to exponential decay.Ī background effect alone can simulate exponential decay, but does not simulate the central island preservation seen in choroideremia. Atrophy growth rates were measured over arbitrary time units and fit to the known exponential decay model. The known anatomic distribution of rods, RPE, choriocapillaris density, amacrine, ganglion, and cone cells were derived from the literature and applied to this model. Two rules were applied to this model: the background effect gave each cell a chance of dying defined by a background function, and the neighbor effect increased the chance of RPE cell death if a neighbor were dead. This means once you are inside the event horizon you cannot point with your finger towards the direction the singularity is located because the singularity happens in your future: no matter where you move, you will "fall" into it.įor macOS 10.To use empirical data to develop a model of cell loss in choroideremia that predicts the known exponential rate of RPE loss and central, scalloped preservation pattern seen in this disease.Ī computational model of RPE loss was created in Python 3.7, which constructed an array of RPE cells clusters, binarized as either live or atrophic.
Schwarzschild black holes are also unique because they have a space-like singularity at their core, which means that the singularity doesn't happen at a specific point in space but happens at a specific point in time (the future). For Sagittarius A* (theīlack hole at the centre of the milky way) this time is approximately 1 minute. Is π*M (in natural units), where M is the mass of the black hole. Horizon, the maximum proper time (which happens when it falls without angular velocity) it will experience to fall into the singularity
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More resourcesĪnd now for something completely differentįor a Schwarzschild black hole (a black hole with no rotation or electromagnetic charge), given a free fall particle starting at the event
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If you have already installed 3.10.0 from here and encounter this problem on macOS 12 Monterey, download and run the updated installer linked below. All other files are unchanged from the original 3.10.0 installer. As of, the macOS 64-bit universal2 installer file for this release was updated to include a fix in the third-party Tk library for this problem.
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You can read the Steering Council communication about it here to learn more.īpo-44828: A change in the newly released macOS 12 Monterey caused file open and save windows in IDLE and other tkinter applications to be unusable. In previous pre-releases but it has been postponed to Python 3.11 due to some compatibility concerns. PEP 597 - Add optional EncodingWarningīpo-38605: from _future_ import annotations ( PEP 563) used to be on this list.PEP 624 - Remove Py_UNICODE encoder APIs.PEP 644 - Require OpenSSL 1.1.1 or newer.PEP 636 - Structural Pattern Matching: Tutorial.PEP 635 - Structural Pattern Matching: Motivation and Rationale.PEP 634 - Structural Pattern Matching: Specification.bpo-12782: Parenthesized context managers are now officially allowed.PEP 618 - Add Optional Length-Checking To zip.PEP 626 - Precise line numbers for debugging and other tools.PEP 612 - Parameter Specification Variables.PEP 604 - Allow writing union types as X | Y.PEP 623 - Deprecate and prepare for the removal of the wstr member in PyUnicodeObject.
Major new features of the 3.10 series, compared to 3.9Īmong the new major new features and changes so far: Python 3.10.0 is the newest major release of the Python programming language, and it contains many new features and optimizations. This is the stable release of Python 3.10.0
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